Bad luck vs lifestyle…Hooray! Science is finally proving the obvious.
A recent study published in Nature entitled “Substantial contribution of extrinsic risk factors to cancer development,” not only successfully rebutted the absurd claim that biology and “disease” originate and are managed by the capricious nature inherent in the cell but, best of all, brought this madness into the public arena.
There is light being shed on the common sense understanding that cellular activity occurs in response to the environment.
Much of the scientific conclusion, especially in the field of medicine are so contrary to common sense that their continued dissemination to the populace requires a ‘hypnotic trance’ to overpower what is left of their over-entertained intellect, housed in an overfed, defiled body. The paper that inspired this rebuttal had concluded that cancer develops as a consequence of ‘bad luck’ (random mutations) saying that “variation in cancer risk among tissues can be explained by the number of stem cell divisions.”
Hannun and his team at Stony Brook University reminded the scientific world of the obvious and incorruptible evidence that comes from epidemiology. It has been know for many years that people who migrate from regions of lower cancer (or any other “disease”) to regions with higher risk soon develop the same “disease” profiles as the natives of the region to which they migrate.
During the American-Korean war that began in 1945, it was observed that there were striking differences in the condition of the coronary (heart) arteries between the Korean and American
corpses. That is, the young Korean men had fairly pristine arteries, while the young Americans were already showing significant signs of plaque buildup. These observations resulted in the
Framingham Heart Study, which initiated in 1948 with 5,209 adult subjects from Framingham Massachusetts, and is now in its third generation. Consequently, it is now well known that diet
and exercise and other lifestyle activities are what cause these differences.
This subject was further explored and stimulated a multitude of studies looking at coronary heart disease, stroke and hypertension and comparing them with people born in Japan who remained
there with those who were born in Japan and moved to either Hawaii or California. In the 1970’s, Robertson TL, Kato H and Rhoads GG concluded, “A striking increase in the incidence of myocardial infarction appears to have occurred in the Japanese who migrated to the United States; this increase is more pronounced in California than in Hawaii.” Why? Because the diets of Japanese who migrated to Hawaii were closer to the original, while the diets of those who migrated to California were much more American.
This same phenomenon known as the “migrant effect” has been demonstrated repeatedly since the 1960’s in literally thousands of scientific papers with regards to cancer development.
So it was bad luck and not the excessive and frequent amount of eating pizza’s that caused the weight gain, right?
One recent paper entitled “Vegetarian Dietary Patterns and the Risk of Colorectal Cancers” concluded, “Vegetarian diets are associated with an overall lower incidence of colorectal cancers.”
Researchers at Loma Linda University in California looked at the dietary habits of more than 70,000 people. Vegetarians had a 22% lower risk of colorectal cancer than non-vegetarians. It must be understood that this study does not prove that a vegetarian diet produces this lower risk, but that it is simply associated. If we follow this reasoning, we must assume that cigarette smoking, too, is associated with an increase in lung cancer.
In the paper by Hannun, et al it was found that “mutations during cell division rarely build up to the point of producing cancer, even in tissues with relatively high rates of cell division.” In fact, they found that exposure to environmental factors are necessary to “trigger disease.”
This fact is nowhere more evident than with the BRCA genes. Men or women may be born with in inherited defective chromosome from one parent, but in order for the defect to be relevant to the individual, they need to develop what is called a somatic mutation. That is, there must be sufficient environmental factors to cause a mutation on the other chromosome during the current lifetime of the individual.
This is why the conventional “wisdom” states that BRCA can “skip” generations…a concept that defies common sense. If a person leads a healthy life, they will not ‘earn’ a somatic mutation and hence will not be at risk for the evils of BRCA gene mutations.
So, here we are…skiing is associated with sprained or broken ankles while tickling is associated with laughter. Let us all be continually vigilant not to draw the politically incorrect conclusions of ‘cause and effect’, even when it is obvious.
1. S. Wu et al. Nature http://dx.doi.org/10.1038/nature16166; 2015 http://www.nature.com/nature/journal/v529/n7584/full/nature16166.html
2. C. Tomasetti, B. Vogelstein Science 347, 78–81; 2015 http://www.sciencemag.org/content/347/6217/78
3. Robertson TL, Kato H, Rhoads GG, et. al in the Am J Cardiol. 1977 Feb;39(2):239-43 http://www.ncbi.nlm.nih.gov/pubmed/835482
4. JAMA Intern Med. 2015;175(5):767-776. doi:10.1001/jamainternmed.2015.59 http://www.ncbi.nlm.nih.gov/pubmed/25751512